For many centuries, scientists have been seeking to determine the quantitative and qualitative composition of animate and inanimate matter. These pioneers’ thirst for knowledge prepared the ground for the field of instrumental elemental analysis. Elemental analysis influences our day-to-day lives – even though we do not really notice it. An important field of application involves the development and quality control of a diverse range of products, such as from the foods and pharmaceuticals sector, as well as metals used in vehicle construction. Moreover, elemental analysis can contribute to a clean environment by delivering an important decision-making basis for environmental and climate protection measures.

I was born in 1803 and worked as a chemistry professor in Giessen, Germany, from 1824 to 1852 before moving on to my own institute in Munich, where I lived and worked until my death 150 years ago at the age of 70. But my spirit lives on and watches how the world continues to develop. It is not without pride that I say that I was regarded as one of the most famous chemists and scientists of my lifetime, and I am often called the father of organic chemistry. I used my laboratory in Giessen for experimenting and teaching in equal measure, making me a pioneer of all branches of experimental research in the sciences. You can take a look at my laboratory to this day at the Liebig Museum in Giessen.

He loved to experiment and was thus one of the pioneers of chemistry as a science and of the chemical analysis itself. Around 100 years later, the chemists Antoine Laurent Lavoisier (1743–1794) and Joseph-Louis Gay-Lussac (1778–1850) laid the foundation for the principle of organic elemental analysis. To this day, this principle is based on combusting a sample followed by the qualitative determination of the reaction gases. Lavoisier, for example, analyzed waxes, oils and fats and discovered that all organic matter contained carbon, hydrogen and oxygen. However, the exact share of each of the elements remained a mystery.

Jöns Jacob Berzelius (1779–1848) changed all of that. The Swedish chemist recognized that chemical synthesis paths for new chemicals can only be tracked in a targeted manner with the assistance of elemental analysis. He used a horizontally positioned combustion tube to combust the sample. This allowed him to heat the substance mixture more evenly, giving him more precise values. He used calcium chloride to absorb the water produced during combustion.

This innovation allowed me and my students to conduct far more analyses in a specific amount of time than Berzelius was able to do. This improved elemental analysis method made me the founder of organic chemistry, as the carbon and hydrogen in organic compounds could now be determined quickly and routinely. And it would have been impossible to determine the structures of organic substances without organic elemental analysis.

Of course, the progress of organic elemental analysis was by no means over with the invention of my five-bulb apparatus: However, this and the other innovations by the pioneers of elemental analysis created the basis for organic elemental analysis by combusting the sample and determining the main components of carbon, hydrogen and nitrogen. The method was progressively refined and perfected over the following years. But I’ll explain more on that when we meet again (see part 2 of this series).